Endocrine Abstracts

Introduction: Hypothyroidism in pregnancy is a topic widely studied in recent years, especially in those women with positive autoimmunity. However, usually the only determination of antibodies that is made is the thyroid antiperoxidase antibodies (anti-TPO). In this study we wanted to know what incidence of anti-thyroglobulin antibodies (anti-Tg) our pregnant women present and what repercussion they can have on thyroid function.Materials and methods: Ant...

This is a 38-year-old male, a regular user of a gym with the sole purpose of improving his physical performance and muscular strength and habitual consumer of hyperproteic dietary supplements. Among his PAs he denies toxic habits, and highlights the removal of the right testicle in childhood. Consultation for decreased desire and sexual potency, together with pain and turgor in the left breast; hair loss at the frontal level, in analytic carried out by the Primary Care Physici...

Background: We report a case of a patient with an ileocecal neuroendocrine tumor (NET) metastatic to both breasts, for whom the initial clinical presentation was chronic diarrhea Breast metastases were initially suspected by a 68-Gallium DOTANOC PET/CT and were confirmed by histopathology. We also performed a comprehensive (non-systematic) literature review through which we identified 116 cases of NENs metastatic to breast.Methods: Case report and compre...

Introduction and objective: Treatment with integrated continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring systems (CGM) helps to improve glycaemic control in people with type 1 diabetes mellitus (DM1). There is increasing use in pregnant women, but there are no protocols for its continuation during delivery. The aim of this work is to analyse glycaemic control during pregnancy, in addition to studying obstetric and neonatal outcomes.<p class="...

Introduction: Pregnancy involves distinct metabolic stages, initially characterized by maternal anabolism, followed by a catabolic phase driven by placental lactogen and various cytokines, leading to varying degrees of insulin resistance. DM is the most common metabolic disorder linked to pregnancy.Objective: The study aimed to detail the clinical characteristics, obstetric complications, and neonatal outcomes of patients with GDM and their children....

Introduction: T2DM is associated with an increased risk of fractures. This heightened risk is attributed to factors such as prolonged disease duration and chronic glycemic control. Interestingly, despite this increased fracture risk, patients with T2DM often exhibit normal or even elevated BMD compared to non-diabetic individuals. This phenomenon is thought to be a result of reduced bone remodeling, coupled with changes in bone microarchitecture.Objectiv...

Objective: Analysis of referrals from Primary Care to the Endocrinology Department for analytical findings of elevated prolactin levels and their subsequent management after initial assessment.Material and methods: Retrospective descriptive study of 118 patients who were referred to the Endocrinology and Nutrition department of the Dos Hermanas Peripheral Specialities Centre between October 2020 and December 2022. Patients already diagnosed with hyperpro...

Introduction: Moderate hyperprolactinaemia occurring in a patient with a normal pituitary MRI, assuming macroprolactin and stress are excluded, is generally considered to be due to a lesion below the level of detection of the MRI scanner. Most patients with mild-moderate hyperprolactinaemia and a normal MRI respond to dopamine agonist therapy. We describe a patient who had prolactin elevation typical of a prolactin-secreting macroadenoma, but with a normal MRI, and in whom the...

Background: Acromegaly is a slowly progressive rare disease caused by an increase in growth hormone secretion that causes a subsequent rise in insulin-like growth factor (IGF-1), both contributing to the excessive growth of the extremities, soft tissues and organs, in addition to other comorbidities directly interfering with patient’s quality of life. Acromegaly patients are concerned about their disease and their treatments, however, publications about patient’s opi...

Molecular mechanisms involved in lactotrophs cell proliferation that led to prolactinoma development are not fully understood. Cyclin-dependant kinase (CDK) p27Kip1 is a key cell cycle regulator, and it is regulated by Menin. The transgenic mice model MEN1+/-, as the p27 -/- knock-out mice, develop pituitary adenomas and other neuroendocrine tumours. Menin can also interfere with phosphorylated AKT (pAKT) function, known for i...